Hydralazine
Included In This Lesson
Study Tools For Hydralazine
Outline
Overview
- Hydralazine- direct acting vasodilator
- Indications
- Hypertension
- Heart failure
- Mechanism of action
- Unclear
- 3 types of mechanism suggested
- Releases nitric oxide from vascular endothelial cells causing vasodilation
- Blocks the entry of calcium in the smooth muscle cells and causing vasodilation.
- Opening the potassium channels causing the hyperpolarization and causing the vasodilation
- Indications
General
- Hydralazine is often given in hospital to quickly lower blood pressure
- Often given with a diuretic for best effect
Assessment
- Assessing for side effects
- Headache
- Dizziness
- Flushing
- Tachycardia and palpiations
- Edema
Therapeutic Management
- Monitor blood pressure frequently at the start of therapy
- Discontinue slowly to avoid rapid rise in blood pressure
Nursing Concepts
- Perfusion
- Hydralazine affects perfusion by decreasing the work load of the heart.
- Pharmacology
- Hydralazine is often prescribed to treat hypertension.
Patient Education
- Caution patients to avoid sudden changes in position to prevent orthostatic hypotension.
- Patients should weigh themselves and monitor for fluid retention.
Transcript
So, in this one, we gonna talk about the hydralazine. This medication doesn’t fall in any category because its mechanism of actions is really unknown. There are many mechanisms are suggested and nothing’s really established with this medication. So, we can say this medication is direct-acting vasodilator. So, that’s just like its own drug, no category.
Let’s talk about the mechanism of action. It is not clear at all. So, here, you can see, there are like 3 types of mechanism suggested that this medication may be working by, but nothing specific. The first one is by releasing nitric oxide from vascular endothelial cells and causing vasodilation. Same as nitroglycerin and sodium nitroprusside like nitro compounds. Or, maybe, by blocking the entry of calcium in the smooth muscle cells and causing vasodilation, same as calcium-channel blocker. And this is not specific, they’re thinking it may be working by that or both. Or, it maybe opening the potassium channels and causing the hyperpolarization and causing the vasodilation. So, these 3 mechanism of action are not, they think the medication maybe working by this mechanism but nothing specific. This mechanism, depending on the mechanism, causes the vasodilation.
This medication maybe used for hypertension, and heart failure. The reason we use this medication for the heart failure, because when we decrease the blood pressure, it’s basically decreasing the afterload. So, when heart left ventricle pumps up the blood into the aorta. If it is decreased blood pressure, that means if aorta and all the arteries are dilated, the left ventricle doesn’t have to push hard or pump hard in order to eject the blood out of the heart into the systemic circulation. So, that’s why it decreases the work load of the heart by decreasing the blood pressure and that’s why it can be used in heart failure as well. But the main reason or the main use for this medication have seen quite often in hospitals or if a patient has high blood pressure.
What are the side effects? This medication works by dilating the vessels, it causes the headache, because when you have dilated vessels in the brain, it holds more blood, it causes the pressure on the brain cells, it causes the headache. So, like, the way it works. It causes the flushing, tachycardia, and lupus like syndrome. And this is the main one, not really often, but sometime they may ask this Hydralizine causes side effects, so, Lupus like syndrome, it can cause.
So, this is really a short drug and this doesn’t fall in any category, so, I just want to cover it separately, mainly used for the hypertension. If you have any question about this drug, feel free to ask us questions. Thanks for watching.
Tiona RN
Concepts Covered:
- Studying
- Medication Administration
- Adult
- Emergency Care of the Cardiac Patient
- Intraoperative Nursing
- Microbiology
- Cardiac Disorders
- Vascular Disorders
- Nervous System
- Upper GI Disorders
- Central Nervous System Disorders – Brain
- Immunological Disorders
- Fundamentals of Emergency Nursing
- Dosage Calculations
- Understanding Society
- Circulatory System
- Concepts of Pharmacology
- Hematologic Disorders
- Newborn Care
- Adulthood Growth and Development
- Disorders of Pancreas
- Postoperative Nursing
- Pregnancy Risks
- Neurological
- Postpartum Complications
- Noninfectious Respiratory Disorder
- Peripheral Nervous System Disorders
- Learning Pharmacology
- Prenatal Concepts
- Tissues and Glands
- Developmental Considerations
- Factors Influencing Community Health
- Childhood Growth and Development
- Prenatal and Neonatal Growth and Development
- Developmental Theories
- Basic
- Neonatal
- Pediatric
- Gastrointestinal
- Newborn Complications
- Labor Complications
- Fetal Development
- Terminology
- Labor and Delivery
- Postpartum Care
- Communication
- Basics of Mathematics
- Statistics
- Basics of Sociology
- Cardiovascular
- Shock
- Shock
- Disorders of the Posterior Pituitary Gland
- Endocrine
- Disorders of the Thyroid & Parathyroid Glands
- Liver & Gallbladder Disorders
- Lower GI Disorders
- Respiratory
- Delegation
- Perioperative Nursing Roles
- Acute & Chronic Renal Disorders
- Respiratory Emergencies
- Disorders of the Adrenal Gland
- Documentation and Communication
- Preoperative Nursing
- Legal and Ethical Issues
- Oncology Disorders
- Female Reproductive Disorders
- Musculoskeletal Trauma
- Renal Disorders
- Male Reproductive Disorders
- Sexually Transmitted Infections
- Infectious Respiratory Disorder
- Integumentary Disorders
- Emergency Care of the Trauma Patient
- Urinary Disorders
- Musculoskeletal Disorders
- EENT Disorders
- Neurological Emergencies
- Disorders of Thermoregulation
- Neurological Trauma
- Basics of NCLEX
- Integumentary Important Points
- Multisystem
- Test Taking Strategies
- Urinary System
- Emergency Care of the Neurological Patient
- Central Nervous System Disorders – Spinal Cord
- Respiratory System
- Emergency Care of the Respiratory Patient
- Cognitive Disorders
- Anxiety Disorders
- Depressive Disorders
- Trauma-Stress Disorders
- Substance Abuse Disorders
- Bipolar Disorders
- Psychotic Disorders
- Concepts of Mental Health
- Eating Disorders
- Personality Disorders
- Health & Stress
- Psychological Emergencies
- Somatoform Disorders
- Prioritization
- Community Health Overview
- Gastrointestinal Disorders
- Integumentary Disorders
- Respiratory Disorders
- Neurologic and Cognitive Disorders
- Renal and Urinary Disorders
- Infectious Disease Disorders
- EENT Disorders
- Hematologic Disorders
- Cardiovascular Disorders
- Musculoskeletal Disorders
- Endocrine and Metabolic Disorders
- Oncologic Disorders
- Behavior
- Emotions and Motivation
- Growth & Development
- Intelligence and Language
- Psychological Disorders
- State of Consciousness
- Note Taking
- Concepts of Population Health
- Basics of Human Biology