Malignant Hyperthermia

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Outline

Overview

  1. Malignant hyperthermia (MH)
    1. Rare
    2. Life threatening complication
    3. Associated with anesthesia drugs
      1. Most common
        1. Inhalation anesthetics
        2. Succinylcholine
    4. Occurs in who?
      1. Most often
        1. Children
        2. Adolescents
      2. Genetic concerns
        1. Increase incidence in
          1. Muscular dystrophies
          2. Central core diseases
    5. Hypermetabolic condition
      1. Increased body temperature
      2. See additional signs and symptoms
    6. When can signs occur?
      1. With anesthesia
        1. Induction
        2. Maintenance
        3. Postoperatively
        4. Repeated exposures
    7. Managed by
      1. Anesthesia team
      2. Perioperative team

Nursing Points

General

  1. Signs and symptoms
    1. Hypercarbia
    2. Muscle stiffness
    3. Tachypnea
      1. May not see in paralyzed patient
    4. Dark blood
      1. Seen at operative field
    5. Tachycardia
    6. Hypoxia
    7. Metabolic and respiratory acidosis
    8. Cardiac arrhythmias
    9. Elevation of body temperature
      1. 1 to 2 Celsius degrees every 5 minutes
      2. One of the LAST things to occur!

Assessment

  1. Assess patient before
    1. History of anesthesia reactions
      1. “High fever”
      2. Family history
        1. Has anyone died during surgery?
    2. Genetic issues
    3. Age
  2. If MH suspected
    1. Patient can still have surgery
    2. Anesthesia drugs adjusted
      1. Per anesthesia team

Therapeutic Management

  1. Know facility/anesthesia protocol
    1. Emergency MH cart
      1. Location
      2. What it includes
        1. Medications
        2. Lab tubes
        3. IV solutions
        4. Location of chilled solutions
    2. Time is crucial!
    3. Know your role
  2. Treatment of MH
    1. Primary drug
      1. Dantrolene
        1. Muscle relaxant
    2. Cold IV solutions
    3. Diuretics
    4. Treating cardiac arrhythmias
    5. Correcting acid-base issues
    6. Monitor
      1. Fluid intake
      2. Output

Nursing Concepts

  1. Clinical judgement
  2. Safety
  3. Teamwork & Collaboration

Patient Education

  1. Teach patient
    1. Provide a full medical history
      1. Issues with anesthesia
        1. Personal or family history
    2. Ask questions!

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Transcript

Hi guys!  Today I am going to talk to you a little bit about malignant hyperthermia and the surgery patient.

So what is malignant hyperthermia?  Guys I will be honest this is something we as the perioperative team especially anesthesia take super seriously!  This condition is rare but extremely life threatening to a patient if it occurs! It can be triggered by certain medications that are given to put the patient under general anesthesia for their surgery.  It can occur in anyone but is commonly seen in children, adolescents, and has an increased incidence with certain genetic conditions like some muscular dystrophies. Guys prevention is key with MH!

So it’s super important to know the signs and symptoms so we can act quickly!  Hypercarbia, muscle stiffness or rigidity are seen. Also tachypnea can be seen but possibly not if the patient has been paralyzed for the surgery.  Also the patients blood may look very desaturated or dark at the surgical field. A high heart rate, low oxygen saturation and acidosis, metabolic and respiratory can be seen too.

Now here is the sign that gives this condition its name!  One of the last signs that is seen is an elevated body temperature and guys it will rise 1 to 5 celsius degrees every 5 minutes!  This is why it is important to recognize initial signs and symptoms to stop this from happening immediately!

So when can malignant hyperthermia occur?  So the signs can occur during induction or maintenance of anesthesia and also after the procedure.  And guys it might not occur after the first time with anesthesia but it could occur after the second surgery!  Guys I have been a surgery nurse for a long time and I will be honest I haven’t seen malignant hyperthermia! I will attribute this to a great assessment by anesthesia and the perioperative team and also a protocol in place that everyone is aware of!  And I just want to mention that we need to be prepared for malignant hyperthermia in settings other than the operating room especially in the ER where patients may be given anesthetic medications like emergent intubation! We always have to be ready for malignant hyperthermia when anesthesia is involved!

Ok so in terms of malignant hyperthermia what should we assess in the patient?  We want to ask our patients if they have ever had any issues that they can remember with anesthesia in the past.  Patients are not always good historians so asking them about “high fevers” or “heat strokes” during or after surgery can help them to remember.  Also sometimes patients might say that they’ve never had surgery but they did have a family member who died during surgery, this could be an indication of MH.  Also assess the patient for any genetic conditions that could increase their risk as well as their age.

Ok guys what do we do if we suspect that our patient may have had or has a family history of malignant hyperthermia?  It is super important to know your facility protocol and guidelines for this issue. So know your role in this situation!  Most facilities, the hospital where I work included, typically have an emergency malignant hyperthermia cart. If we think there is a chance of malignant hyperthermia the cart will be placed outside of the OR so it is readily available.  You should also be aware of what is inside the cart so you have everything you need. Time is critical and crucial to your patient’s life if they have malignant hyperthermia!

So what do we use to treat the patient who is showing signs of malignant hyperthermia? The primary drug used to treat this issue is dantrolene which is a muscle relaxant. The patient will also be treated with cold IV solutions, diuretics, arrhythmias and acid-base issues will be corrected, and fluid intake and output will be monitored.  Instructions and supplies are typically included with the emergency MH cart.

Okay so which nursing concepts can we apply to malignant hyperthermia? Clinical judgement is crucial for the safety of the malignant hyperthermia patient. The anesthesia team and perioperative team members will work together and collaborate for prevention of malignant hyperthermia or treatment if necessary.

Okay so let’s look at a few key points of malignant hyperthermia. This condition is rare but life-threatening if it occurs.   It’s commonly associated with general anesthesia medications, it can occur in anyone but there is an increased incidence in children, adolescents, and patients with certain genetic conditions.  Signs of malignant hyperthermia are hypercarbia, hypoxia, muscle stiffness or rigidity, dark blood that can be seen during surgery and one of the last signs to occur is an elevated temperature. We will assess our patients preoperatively for any history of anesthesia reactions or a “high fever” that they can remember during or after a surgery. We are also going to ask them about any family history of anesthesia reactions. If we recognize something we will notify anesthesia and they can alter their anesthesia medications for prevention.   Know your facilities policy and guidelines and also where your emergency MH cart is. If MH occurs in your patient dantrolene is the primary drug for treatment. We also use chilled IV solutions, treat acid base issues and cardiac arrhythmias, and diuretics are also given. We teach our patients to provide a thorough medical and surgical history and also a family history and as always they can ask questions!

Okay guys I hope you enjoyed this lesson and learned important information on malignant hyperthermia!  Make sure you check out all the resources attached to this lesson, as well as the rest of the lessons in this course. Now, go out and be your best self today. And, as always, happy nursing!

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Concepts Covered:

  • Noninfectious Respiratory Disorder
  • Test Taking Strategies
  • Respiratory Disorders
  • EENT Disorders
  • Prenatal Concepts
  • Studying
  • Prefixes
  • Suffixes
  • Acute & Chronic Renal Disorders
  • Disorders of the Adrenal Gland
  • Integumentary Disorders
  • Oncology Disorders
  • Preoperative Nursing
  • Musculoskeletal Trauma
  • Bipolar Disorders
  • Disorders of the Posterior Pituitary Gland
  • Hematologic Disorders
  • Community Health Overview
  • Immunological Disorders
  • Renal Disorders
  • Childhood Growth and Development
  • Labor Complications
  • Upper GI Disorders
  • Medication Administration
  • Neurological Emergencies
  • Adulthood Growth and Development
  • Disorders of Pancreas
  • Musculoskeletal Disorders
  • Cardiac Disorders
  • Disorders of the Thyroid & Parathyroid Glands
  • Integumentary Important Points
  • Pregnancy Risks
  • Urinary Disorders
  • Vascular Disorders
  • Eating Disorders
  • Learning Pharmacology
  • Anxiety Disorders
  • Basics of NCLEX
  • Factors Influencing Community Health
  • Lower GI Disorders
  • Intraoperative Nursing
  • Integumentary Disorders
  • Neurologic and Cognitive Disorders
  • Trauma-Stress Disorders
  • Central Nervous System Disorders – Brain
  • Somatoform Disorders
  • Dosage Calculations
  • Depressive Disorders
  • Personality Disorders
  • Cognitive Disorders
  • Substance Abuse Disorders
  • Psychological Emergencies
  • Circulatory System
  • Postoperative Nursing
  • Hematologic Disorders
  • Liver & Gallbladder Disorders
  • Infectious Respiratory Disorder
  • Central Nervous System Disorders – Spinal Cord
  • Emergency Care of the Cardiac Patient
  • Concepts of Population Health
  • Peripheral Nervous System Disorders
  • Note Taking
  • Female Reproductive Disorders
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  • Postpartum Complications
  • Endocrine and Metabolic Disorders
  • Fetal Development
  • Shock
  • Emergency Care of the Neurological Patient
  • Respiratory Emergencies
  • Labor and Delivery
  • Gastrointestinal Disorders
  • EENT Disorders
  • Postpartum Care
  • Cardiovascular Disorders
  • Newborn Care
  • Renal and Urinary Disorders
  • Newborn Complications
  • Urinary System
  • Musculoskeletal Disorders
  • Infectious Disease Disorders
  • Nervous System
  • Psychotic Disorders

Study Plan Lessons

Nursing Care and Pathophysiology of COPD (Chronic Obstructive Pulmonary Disease)
12 Points to Answering Pharmacology Questions
ABGs Nursing Normal Lab Values
Care of the Pediatric Patient
Glaucoma
Menstrual Cycle
Time Management
X-Ray (Xray)
54 Common Medication Prefixes and Suffixes
ABG (Arterial Blood Gas) Interpretation-The Basics
Nursing Care and Pathophysiology of Acute Kidney (Renal) Injury (AKI)
Addisons Disease
Burn Injuries
Cataracts
Computed Tomography (CT)
Family Planning & Contraception
Informed Consent
Lung Sounds
Study Setting
Vitals (VS) and Assessment
Alveoli & Atelectasis
Nursing Care and Pathophysiology for Cushings Syndrome
Goal Setting
Macular Degeneration
Magnetic Resonance Imaging (MRI)
Preoperative (Preop)Assessment
Pressure Ulcers/Pressure injuries (Braden scale)
Therapeutic Drug Levels (Digoxin, Lithium, Theophylline, Phenytoin)
Nursing Care and Pathophysiology for Diabetes Insipidus (DI)
Nursing Care and Pathophysiology for Disseminated Intravascular Coagulation (DIC)
Epidemiology
Essential NCLEX Meds by Class
Gas Exchange
Nursing Care and Pathophysiology of Glomerulonephritis
Growth & Development – Infants
Nursing Care and Pathophysiology for Herpes Zoster – Shingles
Isotonic Solutions (IV solutions)
Nursing Care and Pathophysiology of Osteoarthritis (OA)
Nursing Care and Pathophysiology for Pancreatitis
Preoperative (Preop) Education
6 Rights of Medication Administration
Cerebral Angiography
Growth & Development – Toddlers
Health Promotion & Disease Prevention
Hearing Loss
Hypotonic Solutions (IV solutions)
Nursing Care and Pathophysiology of Osteoporosis
Nursing Care and Pathophysiology for Peptic Ulcer Disease (PUD)
Preoperative (Preop) Nursing Priorities
Respiratory Acidosis (interpretation and nursing interventions)
Thrombocytopenia
Blood Transfusions (Administration)
Cardiovascular Angiography
Fractures
Growth & Development – Preschoolers
Nursing Care and Pathophysiology for Hyperthyroidism
Hypertonic Solutions (IV solutions)
Integumentary (Skin) Important Points
Preload and Afterload
Respiratory Alkalosis
Nursing Care and Pathophysiology of Urinary Tract Infection (UTI)
Echocardiogram (Cardiac Echo)
Growth & Development – School Age- Adolescent
Nursing Care and Pathophysiology for Hypothyroidism
Metabolic Acidosis (interpretation and nursing diagnosis)
Performing Cardiac (Heart) Monitoring
Metabolic Alkalosis
The SOCK Method – Overview
Ultrasound
The SOCK Method – S
The SOCK Method – O
Base Excess & Deficit
The SOCK Method – C
The SOCK Method – K
Biopsy
Anxiety
Basics of Calculations
Critical Thinking
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Gestation & Nägele’s Rule: Estimating Due Dates
Potassium-K (Hyperkalemia, Hypokalemia)
Nursing Care and Pathophysiology of Angina
Nursing Care and Pathophysiology for Appendicitis
Nursing Care and Pathophysiology for Asthma
Bloom’s Taxonomy
Nursing Care and Pathophysiology of Chronic Kidney (Renal) Disease (CKD)
Nursing Care and Pathophysiology of Diabetes Mellitus (DM)
Dimensional Analysis Nursing (Dosage Calculations/Med Math)
Environmental Health
General Anesthesia
Generalized Anxiety Disorder
Gravidity and Parity (G&Ps, GTPAL)
Impetigo
Leukemia
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Sodium-Na (Hypernatremia, Hyponatremia)
Nursing Care and Pathophysiology of COPD (Chronic Obstructive Pulmonary Disease)
Diabetes Management
Dialysis & Other Renal Points
Local Anesthesia
Lymphoma
Nursing Care and Pathophysiology of Myocardial Infarction (MI)
Oral Medications
Pediculosis Capitis
Post-Traumatic Stress Disorder (PTSD)
Routine Neuro Assessments
What is the NCLEX?
Adjunct Neuro Assessments
Anatomy of an NCLEX Question
Burn Injuries
Chloride-Cl (Hyperchloremia, Hypochloremia)
Nursing Care and Pathophysiology of Diabetic Ketoacidosis (DKA)
Fundal Height Assessment for Nurses
Injectable Medications
Moderate Sedation
Oncology Important Points
Somatoform
Technology & Informatics
Nursing Care and Pathophysiology of Coronary Artery Disease (CAD)
Hyperglycaemic Hyperosmolar Non-ketotic syndrome (HHNS)
Nursing Care and Pathophysiology for Inflammatory Bowel Disease (IBD)
IV Infusions (Solutions)
Malignant Hyperthermia
Maternal Risk Factors
Complex Calculations (Dosage Calculations/Med Math)
Intracranial Pressure ICP
Mood Disorders (Bipolar)
Nursing Care and Pathophysiology for Ulcerative Colitis(UC)
Cerebral Perfusion Pressure CPP
Nursing Care and Pathophysiology for Crohn’s Disease
Depression
Paranoid Disorders
Personality Disorders
Cognitive Impairment Disorders
Eating Disorders (Anorexia Nervosa, Bulimia Nervosa)
Alcohol Withdrawal (Addiction)
Grief and Loss
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Normal Sinus Rhythm
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Post-Anesthesia Recovery
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SATA
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Absolute Words
Nursing Care and Pathophysiology for Acquired Immune Deficiency Syndrome (AIDS)
Nursing Care and Pathophysiology for Cholecystitis
Discomforts of Pregnancy
Nursing Care and Pathophysiology for Heart Failure (CHF)
Hemoglobin (Hbg) Lab Values
Nursing Care and Pathophysiology for Influenza (Flu)
Nursing Care and Pathophysiology for Multiple Sclerosis (MS)
Postoperative (Postop) Complications
Sinus Bradycardia
Nursing Care and Pathophysiology for Anaphylaxis
Antepartum Testing
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Hemophilia
Nursing Care and Pathophysiology for Hepatitis (Liver Disease)
Opposites
Sinus Tachycardia
Nursing Care and Pathophysiology for Tuberculosis (TB)
Nursing Care and Pathophysiology for Cirrhosis (Liver Disease, Hepatic encephalopathy, Portal Hypertension, Esophageal Varices)
Discharge (DC) Teaching After Surgery
Nutrition in Pregnancy
Pacemakers
Nursing Care and Pathophysiology of Pneumonia
Same
White Blood Cell (WBC) Lab Values
Atrial Fibrillation (A Fib)
Communicable Diseases
Platelets (PLT) Lab Values
Priority
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Disasters & Bioterrorism
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Acute vs Chronic
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Premature Ventricular Contraction (PVC)
What do you want me to know?
Duplicate Facts
Ventricular Tachycardia (V-tach)
Repeating Words
Ventricular Fibrillation (V Fib)
Denying Feelings
NCLEX® Question Traps
Albumin Lab Values
Outline Question Method (Note taking)
Nursing Care and Pathophysiology for Pelvic Inflammatory Disease (PID)
Benzodiazepines
Cholesterol (Chol) Lab Values
Drawing Pictures
Nursing Care and Pathophysiology for Hemorrhagic Stroke (CVA)
Nursing Care and Pathophysiology of Hypertension (HTN)
Ammonia (NH3) Lab Values
Artificial Airways
Nursing Care and Pathophysiology for Endometriosis
Nursing Care and Pathophysiology for Ischemic Stroke (CVA)
Nephroblastoma
Airway Suctioning
Chorioamnionitis
Nursing Care and Pathophysiology for Menopause
Stroke Assessment (CVA)
Nursing Care and Pathophysiology for Cardiomyopathy
Gestational Diabetes (GDM)
Stroke Therapeutic Management (CVA)
Disseminated Intravascular Coagulation (DIC)
Stroke Nursing Care (CVA)
Ectopic Pregnancy
Nursing Care and Pathophysiology for Thrombophlebitis (clot)
Hydatidiform Mole (Molar pregnancy)
Gestational HTN (Hypertension)
Infections in Pregnancy
Preeclampsia: Signs, Symptoms, Nursing Care, and Magnesium Sulfate
Blood Urea Nitrogen (BUN) Lab Values
Fever
Creatinine (Cr) Lab Values
Dehydration
Fetal Development
Nursing Care and Pathophysiology for Hypovolemic Shock
Seizure Causes (Epilepsy, Generalized)
Nursing Care and Pathophysiology for Cardiogenic Shock
Fetal Environment
Seizure Assessment
Chest Tube Management
Nursing Care and Pathophysiology for Distributive Shock
Fetal Circulation
Seizure Therapeutic Management
Urinalysis (UA)
Nursing Care and Pathophysiology for Seizure
Glucose Lab Values
Process of Labor
Vomiting
Pediatric Gastrointestinal Dysfunction – Diarrhea
Hemoglobin A1c (HbA1C)
Mechanisms of Labor
Leopold Maneuvers
Celiac Disease
Fetal Heart Monitoring (FHM)
Nursing Care and Pathophysiology for Meningitis
Appendicitis
Intussusception
Constipation and Encopresis (Incontinence)
Conjunctivitis
Prolapsed Umbilical Cord
Acute Otitis Media (AOM)
Placenta Previa
Abruptio Placentae (Placental abruption)
Tonsillitis
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Precipitous Labor
Dystocia
Postpartum Physiological Maternal Changes
Bronchiolitis and Respiratory Syncytial Virus (RSV)
MAOIs
Postpartum Discomforts
Breastfeeding
Asthma
SSRIs
Cystic Fibrosis (CF)
TCAs
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Defects of Increased Pulmonary Blood Flow
Postpartum Hemorrhage (PPH)
Defects of Decreased Pulmonary Blood Flow
Mastitis
Insulin
Obstructive Heart (Cardiac) Defects
Mixed (Cardiac) Heart Defects
Histamine 1 Receptor Blockers
Initial Care of the Newborn (APGAR)
Nephrotic Syndrome
Enuresis
Newborn Physical Exam
Body System Assessments
Histamine 2 Receptor Blockers
Newborn Reflexes
Babies by Term
Cerebral Palsy (CP)
Renin Angiotensin Aldosterone System
Meconium Aspiration
Meningitis
Transient Tachypnea of Newborn
Hyperbilirubinemia (Jaundice)
Spina Bifida – Neural Tube Defect (NTD)
ACE (angiotensin-converting enzyme) Inhibitors
Autism Spectrum Disorders
Attention Deficit Hyperactivity Disorder (ADHD)
Newborn of HIV+ Mother
Angiotensin Receptor Blockers
Calcium Channel Blockers
Cardiac Glycosides
Scoliosis
Metronidazole (Flagyl) Nursing Considerations
Ciprofloxacin (Cipro) Nursing Considerations
Vancomycin (Vancocin) Nursing Considerations
Anti-Infective – Penicillins and Cephalosporins
Atypical Antipsychotics
Rubeola – Measles
Mumps
Varicella – Chickenpox
Pertussis – Whooping Cough
Autonomic Nervous System (ANS)
Sympathomimetics (Alpha (Clonodine) & Beta (Albuterol) Agonists)
Parasympathomimetics (Cholinergics) Nursing Considerations
Parasympatholytics (Anticholinergics) Nursing Considerations
Diuretics (Loop, Potassium Sparing, Thiazide, Furosemide/Lasix)
Epoetin Alfa
HMG-CoA Reductase Inhibitors (Statins)
Magnesium Sulfate
NSAIDs
Corticosteroids
Hydralazine (Apresoline) Nursing Considerations
Nitro Compounds
Vasopressin
Nursing Care and Pathophysiology of Acute Kidney (Renal) Injury (AKI)
Nursing Care and Pathophysiology for Anemia
Nursing Care and Pathophysiology for Heart Failure (CHF)
Nursing Care and Pathophysiology of Diabetes Mellitus (DM)
Dissociative Disorders
Eczema
Fractures
Hemodynamics
Nursing Care and Pathophysiology for Hemorrhagic Stroke (CVA)
Nursing Care and Pathophysiology of Myocardial Infarction (MI)
Nursing Care and Pathophysiology for Parkinsons
Asthma
Pediatric Gastrointestinal Dysfunction – Diarrhea
Postpartum Hemorrhage (PPH)
Preeclampsia: Signs, Symptoms, Nursing Care, and Magnesium Sulfate
Proton Pump Inhibitors
Schizophrenia
Nursing Care and Pathophysiology for SIADH (Syndrome of Inappropriate antidiuretic Hormone Secretion)