Malignant Hyperthermia

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Outline

Overview

  1. Malignant hyperthermia (MH)
    1. Rare
    2. Life threatening complication
    3. Associated with anesthesia drugs
      1. Most common
        1. Inhalation anesthetics
        2. Succinylcholine
    4. Occurs in who?
      1. Most often
        1. Children
        2. Adolescents
      2. Genetic concerns
        1. Increase incidence in
          1. Muscular dystrophies
          2. Central core diseases
    5. Hypermetabolic condition
      1. Increased body temperature
      2. See additional signs and symptoms
    6. When can signs occur?
      1. With anesthesia
        1. Induction
        2. Maintenance
        3. Postoperatively
        4. Repeated exposures
    7. Managed by
      1. Anesthesia team
      2. Perioperative team

Nursing Points

General

  1. Signs and symptoms
    1. Hypercarbia
    2. Muscle stiffness
    3. Tachypnea
      1. May not see in paralyzed patient
    4. Dark blood
      1. Seen at operative field
    5. Tachycardia
    6. Hypoxia
    7. Metabolic and respiratory acidosis
    8. Cardiac arrhythmias
    9. Elevation of body temperature
      1. 1 to 2 Celsius degrees every 5 minutes
      2. One of the LAST things to occur!

Assessment

  1. Assess patient before
    1. History of anesthesia reactions
      1. “High fever”
      2. Family history
        1. Has anyone died during surgery?
    2. Genetic issues
    3. Age
  2. If MH suspected
    1. Patient can still have surgery
    2. Anesthesia drugs adjusted
      1. Per anesthesia team

Therapeutic Management

  1. Know facility/anesthesia protocol
    1. Emergency MH cart
      1. Location
      2. What it includes
        1. Medications
        2. Lab tubes
        3. IV solutions
        4. Location of chilled solutions
    2. Time is crucial!
    3. Know your role
  2. Treatment of MH
    1. Primary drug
      1. Dantrolene
        1. Muscle relaxant
    2. Cold IV solutions
    3. Diuretics
    4. Treating cardiac arrhythmias
    5. Correcting acid-base issues
    6. Monitor
      1. Fluid intake
      2. Output

Nursing Concepts

  1. Clinical judgement
  2. Safety
  3. Teamwork & Collaboration

Patient Education

  1. Teach patient
    1. Provide a full medical history
      1. Issues with anesthesia
        1. Personal or family history
    2. Ask questions!

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Transcript

Hi guys!  Today I am going to talk to you a little bit about malignant hyperthermia and the surgery patient.

So what is malignant hyperthermia?  Guys I will be honest this is something we as the perioperative team especially anesthesia take super seriously!  This condition is rare but extremely life threatening to a patient if it occurs! It can be triggered by certain medications that are given to put the patient under general anesthesia for their surgery.  It can occur in anyone but is commonly seen in children, adolescents, and has an increased incidence with certain genetic conditions like some muscular dystrophies. Guys prevention is key with MH!

So it’s super important to know the signs and symptoms so we can act quickly!  Hypercarbia, muscle stiffness or rigidity are seen. Also tachypnea can be seen but possibly not if the patient has been paralyzed for the surgery.  Also the patients blood may look very desaturated or dark at the surgical field. A high heart rate, low oxygen saturation and acidosis, metabolic and respiratory can be seen too.

Now here is the sign that gives this condition its name!  One of the last signs that is seen is an elevated body temperature and guys it will rise 1 to 5 celsius degrees every 5 minutes!  This is why it is important to recognize initial signs and symptoms to stop this from happening immediately!

So when can malignant hyperthermia occur?  So the signs can occur during induction or maintenance of anesthesia and also after the procedure.  And guys it might not occur after the first time with anesthesia but it could occur after the second surgery!  Guys I have been a surgery nurse for a long time and I will be honest I haven’t seen malignant hyperthermia! I will attribute this to a great assessment by anesthesia and the perioperative team and also a protocol in place that everyone is aware of!  And I just want to mention that we need to be prepared for malignant hyperthermia in settings other than the operating room especially in the ER where patients may be given anesthetic medications like emergent intubation! We always have to be ready for malignant hyperthermia when anesthesia is involved!

Ok so in terms of malignant hyperthermia what should we assess in the patient?  We want to ask our patients if they have ever had any issues that they can remember with anesthesia in the past.  Patients are not always good historians so asking them about “high fevers” or “heat strokes” during or after surgery can help them to remember.  Also sometimes patients might say that they’ve never had surgery but they did have a family member who died during surgery, this could be an indication of MH.  Also assess the patient for any genetic conditions that could increase their risk as well as their age.

Ok guys what do we do if we suspect that our patient may have had or has a family history of malignant hyperthermia?  It is super important to know your facility protocol and guidelines for this issue. So know your role in this situation!  Most facilities, the hospital where I work included, typically have an emergency malignant hyperthermia cart. If we think there is a chance of malignant hyperthermia the cart will be placed outside of the OR so it is readily available.  You should also be aware of what is inside the cart so you have everything you need. Time is critical and crucial to your patient’s life if they have malignant hyperthermia!

So what do we use to treat the patient who is showing signs of malignant hyperthermia? The primary drug used to treat this issue is dantrolene which is a muscle relaxant. The patient will also be treated with cold IV solutions, diuretics, arrhythmias and acid-base issues will be corrected, and fluid intake and output will be monitored.  Instructions and supplies are typically included with the emergency MH cart.

Okay so which nursing concepts can we apply to malignant hyperthermia? Clinical judgement is crucial for the safety of the malignant hyperthermia patient. The anesthesia team and perioperative team members will work together and collaborate for prevention of malignant hyperthermia or treatment if necessary.

Okay so let’s look at a few key points of malignant hyperthermia. This condition is rare but life-threatening if it occurs.   It’s commonly associated with general anesthesia medications, it can occur in anyone but there is an increased incidence in children, adolescents, and patients with certain genetic conditions.  Signs of malignant hyperthermia are hypercarbia, hypoxia, muscle stiffness or rigidity, dark blood that can be seen during surgery and one of the last signs to occur is an elevated temperature. We will assess our patients preoperatively for any history of anesthesia reactions or a “high fever” that they can remember during or after a surgery. We are also going to ask them about any family history of anesthesia reactions. If we recognize something we will notify anesthesia and they can alter their anesthesia medications for prevention.   Know your facilities policy and guidelines and also where your emergency MH cart is. If MH occurs in your patient dantrolene is the primary drug for treatment. We also use chilled IV solutions, treat acid base issues and cardiac arrhythmias, and diuretics are also given. We teach our patients to provide a thorough medical and surgical history and also a family history and as always they can ask questions!

Okay guys I hope you enjoyed this lesson and learned important information on malignant hyperthermia!  Make sure you check out all the resources attached to this lesson, as well as the rest of the lessons in this course. Now, go out and be your best self today. And, as always, happy nursing!

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Final Exam

Concepts Covered:

  • Terminology
  • Urinary System
  • Respiratory Disorders
  • Acute & Chronic Renal Disorders
  • Disorders of the Adrenal Gland
  • Oncology Disorders
  • Integumentary Disorders
  • Preoperative Nursing
  • Musculoskeletal Trauma
  • Integumentary Disorders
  • Respiratory Emergencies
  • Disorders of the Posterior Pituitary Gland
  • Hematologic Disorders
  • Renal Disorders
  • Labor Complications
  • Immunological Disorders
  • Upper GI Disorders
  • Neurological Emergencies
  • Disorders of Pancreas
  • Musculoskeletal Disorders
  • Cardiac Disorders
  • Disorders of the Thyroid & Parathyroid Glands
  • Integumentary Important Points
  • Pregnancy Risks
  • Urinary Disorders
  • Vascular Disorders
  • Central Nervous System Disorders – Brain
  • Nervous System
  • Lower GI Disorders
  • Intraoperative Nursing
  • Eating Disorders
  • Circulatory System
  • Postoperative Nursing
  • Liver & Gallbladder Disorders
  • Emergency Care of the Cardiac Patient
  • Female Reproductive Disorders
  • Shock
  • Respiratory System
  • Substance Abuse Disorders
  • Fetal Development
  • Proteins
  • Noninfectious Respiratory Disorder
  • Newborn Care
  • Statistics
  • Emergency Care of the Neurological Patient
  • Basics of Sociology
  • Bipolar Disorders
  • Infectious Respiratory Disorder

Study Plan Lessons

Diagnostic Testing Course Introduction
Fluid & Electrolytes Course Introduction
X-Ray (Xray)
X-Ray (Xray)
X-Ray (Xray)
Nursing Care and Pathophysiology of Acute Kidney (Renal) Injury (AKI)
Addisons Disease
Computed Tomography (CT)
Computed Tomography (CT)
Computed Tomography (CT)
Fluid Pressures
Informed Consent
Nursing Care and Pathophysiology for Cushings Syndrome
Fluid Shifts (Ascites) (Pleural Effusion)
Magnetic Resonance Imaging (MRI)
Magnetic Resonance Imaging (MRI)
Magnetic Resonance Imaging (MRI)
Preoperative (Preop)Assessment
Pressure Ulcers/Pressure injuries (Braden scale)
CT & MR Angiography
CT & MR Angiography
Nursing Care and Pathophysiology for Diabetes Insipidus (DI)
Nursing Care and Pathophysiology for Disseminated Intravascular Coagulation (DIC)
Nursing Care and Pathophysiology of Glomerulonephritis
Isotonic Solutions (IV solutions)
Nursing Care and Pathophysiology of Osteoarthritis (OA)
Nursing Care and Pathophysiology for Pancreatitis
Preoperative (Preop) Education
Cerebral Angiography
Cerebral Angiography
Cerebral Angiography
Hypotonic Solutions (IV solutions)
Nursing Care and Pathophysiology of Osteoporosis
Nursing Care and Pathophysiology for Peptic Ulcer Disease (PUD)
Preoperative (Preop) Nursing Priorities
Thrombocytopenia
Blood Transfusions (Administration)
Cardiovascular Angiography
Cardiovascular Angiography
Cardiovascular Angiography
Fractures
Nursing Care and Pathophysiology for Hyperthyroidism
Hypertonic Solutions (IV solutions)
Integumentary (Skin) Important Points
Preload and Afterload
Nursing Care and Pathophysiology of Urinary Tract Infection (UTI)
Echocardiogram (Cardiac Echo)
Echocardiogram (Cardiac Echo)
Echocardiogram (Cardiac Echo)
Nursing Care and Pathophysiology for Hypothyroidism
Performing Cardiac (Heart) Monitoring
Ultrasound
Ultrasound
Interventional Radiology
Interventional Radiology
Nuclear Medicine
Cardiac Stress Test
Cardiac Stress Test
Pulmonary Function Test
Pulmonary Function Test
Endoscopy & EGD
Endoscopy & EGD
Colonoscopy
Colonoscopy
Mammogram
Biopsy
Biopsy
Electroencephalography (EEG)
Electroencephalography (EEG)
Electromyography (EMG)
Electromyography (EMG)
Nursing Care and Pathophysiology of Angina
Nursing Care and Pathophysiology for Appendicitis
Nursing Care and Pathophysiology of Chronic Kidney (Renal) Disease (CKD)
Nursing Care and Pathophysiology of Diabetes Mellitus (DM)
General Anesthesia
Leukemia
Sodium-Na (Hypernatremia, Hyponatremia)
Calcium-Ca (Hypercalcemia, Hypocalcemia)
Diabetes Management
Dialysis & Other Renal Points
Local Anesthesia
Lymphoma
Nursing Care and Pathophysiology of Myocardial Infarction (MI)
Chloride-Cl (Hyperchloremia, Hypochloremia)
Nursing Care and Pathophysiology of Diabetic Ketoacidosis (DKA)
Moderate Sedation
Oncology Important Points
Nursing Care and Pathophysiology of Coronary Artery Disease (CAD)
Hyperglycaemic Hyperosmolar Non-ketotic syndrome (HHNS)
Nursing Care and Pathophysiology for Inflammatory Bowel Disease (IBD)
Magnesium-Mg (Hypomagnesemia, Hypermagnesemia)
Malignant Hyperthermia
Phosphorus-Phos
Nursing Care and Pathophysiology for Ulcerative Colitis(UC)
Nursing Care and Pathophysiology for Crohn’s Disease
Normal Sinus Rhythm
Post-Anesthesia Recovery
Nursing Care and Pathophysiology for Acquired Immune Deficiency Syndrome (AIDS)
Nursing Care and Pathophysiology for Cholecystitis
Nursing Care and Pathophysiology for Heart Failure (CHF)
Postoperative (Postop) Complications
Sinus Bradycardia
Nursing Care and Pathophysiology for Anaphylaxis
Nursing Care and Pathophysiology for Hepatitis (Liver Disease)
Sinus Tachycardia
Nursing Care and Pathophysiology for Cirrhosis (Liver Disease, Hepatic encephalopathy, Portal Hypertension, Esophageal Varices)
Discharge (DC) Teaching After Surgery
Pacemakers
Atrial Fibrillation (A Fib)
Premature Ventricular Contraction (PVC)
Ventricular Tachycardia (V-tach)
Ventricular Fibrillation (V Fib)
Nursing Care and Pathophysiology for Pelvic Inflammatory Disease (PID)
Nursing Care and Pathophysiology of Hypertension (HTN)
Nursing Care and Pathophysiology for Endometriosis
Nursing Care and Pathophysiology for Menopause
Nursing Care and Pathophysiology for Cardiomyopathy
Nursing Care and Pathophysiology for Thrombophlebitis (clot)
Nursing Care and Pathophysiology for Hypovolemic Shock
Nursing Care and Pathophysiology for Cardiogenic Shock
Nursing Care and Pathophysiology for Distributive Shock
ABG (Arterial Blood Gas) Interpretation-The Basics
ABG (Arterial Blood Gas) Oxygenation
ABG Course (Arterial Blood Gas) Introduction
ABGs Nursing Normal Lab Values
ABGs Tic-Tac-Toe interpretation Method
Absolute Neutrophil Count (ANC) Lab Values
Absolute Reticulocyte Count (ARC) Lab Values
Alanine Aminotransferase (ALT) Lab Values
Albumin Lab Values
Alkaline Phosphatase (ALK PHOS) Lab Values
Alpha-fetoprotein (AFP) Lab Values
Ammonia (NH3) Lab Values
Anion Gap
Antinuclear Antibody Lab Values
Base Excess & Deficit
Beta Hydroxy (BHB) Lab Values
Bicarbonate (HCO3) Lab Values
Blood Urea Nitrogen (BUN) Lab Values
Brain Natriuretic Peptide (BNP) Lab Values
C-Reactive Protein (CRP) Lab Values
Carbon Dioxide (Co2) Lab Values
Carboxyhemoglobin Lab Values
Cardiac (Heart) Enzymes
Cholesterol (Chol) Lab Values
Coagulation Studies (PT, PTT, INR)
Congestive Heart Failure (CHF) Labs
COPD (Chronic Obstructive Pulmonary Disease) Labs
Cortisol Lab Vales
Creatine Phosphokinase (CPK) Lab Values
Creatinine (Cr) Lab Values
Creatinine Clearance Lab Values
Cultures
Cyclic Citrullinated Peptide (CCP) Lab Values
D-Dimer (DDI) Lab Values
Direct Bilirubin (Conjugated) Lab Values
Dysrhythmias Labs
Erythrocyte Sedimentation Rate (ESR) Lab Values
Fibrin Degradation Products (FDP) Lab Values
Fibrinogen Lab Values
Fluid Compartments
Free T4 (Thyroxine) Lab Values
Gamma Glutamyl Transferase (GGT) Lab Values
Glomerular Filtration Rate (GFR)
Glucagon Lab Values
Glucose Lab Values
Glucose Tolerance Test (GTT) Lab Values
Growth Hormone (GH) Lab Values
Hematocrit (Hct) Lab Values
Hemodynamics
Hemoglobin (Hbg) Lab Values
Hemoglobin A1c (HbA1C)
Hepatitis B Virus (HBV) Lab Values
Homocysteine (HCY) Lab Values
Ionized Calcium Lab Values
Iron (Fe) Lab Values
Ischemic (CVA) Stroke Labs
Lab Panels
Lab Values Course Introduction
Lactate Dehydrogenase (LDH) Lab Values
Lactic Acid
Lipase Lab Values
Lithium Lab Values
Liver Function Tests
Mean Corpuscular Volume (MCV) Lab Values
Mean Platelet Volume (MPV) Lab Values
Metabolic Acidosis (interpretation and nursing diagnosis)
Metabolic Alkalosis
Methemoglobin (MHGB) Lab Values
Myoglobin (MB) Lab Values
Order of Lab Draws
Pediatric Bronchiolitis Labs
Phosphorus (PO4) Blood Test Lab Values
Platelets (PLT) Lab Values
Pneumonia Labs
Potassium-K (Hyperkalemia, Hypokalemia)
Prealbumin (PAB) Lab Values
Pregnancy Labs
Procalcitonin (PCT) Lab Values
Prostate Specific Antigen (PSA) Lab Values
Protein (PROT) Lab Values
Protein in Urine Lab Values
Red Blood Cell (RBC) Lab Values
Red Cell Distribution Width (RDW) Lab Values
Renal (Kidney) Failure Labs
Respiratory Acidosis (interpretation and nursing interventions)
Respiratory Alkalosis
ROME – ABG (Arterial Blood Gas) Interpretation
Sepsis Labs
Shorthand Lab Values
Nursing Care and Pathophysiology for SIADH (Syndrome of Inappropriate antidiuretic Hormone Secretion)
Thyroid Stimulating Hormone (TSH) Lab Values
Thyroxine (T4) Lab Values
Total Bilirubin (T. Billi) Lab Values
Total Iron Binding Capacity (TIBC) Lab Values
Triiodothyronine (T3) Lab Values
Troponin I (cTNL) Lab Values
Urinalysis (UA)
Urine Culture and Sensitivity Lab Values
Vitamin B12 Lab Values
Vitamin D Lab Values
White Blood Cell (WBC) Lab Values