Anti-Infective – Carbapenems
Included In This Lesson
Outline
Overview
- Overview
- Not normally first-line antibiotics choice
- Bactericidal beta-lactam antibiotics
- Reserved for complicated/severe infections
- Escherichia coli
- Klebsiella pneumoniae
- Drug-induced seizure activity
- Types
- Imipenem-cilastatin
- Meropenem
- Ertapenem
- Doripenem
- Mechanism of action
- Inhibit the synthesis of bacterial cell wall
- Leads to cell death
- Ertapenem
- Indications
- Enterococcal spp
- Pseudomonas spp
- Indications
- Meropenem
- Indications
- Gram + organisms
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Bacterial meningitis
- Indications
- Imipenem-cilastatin
- Indications
- Gram + / gram – aerobic and anaerobic bacteria
- Bone, joint, skin, and soft tissue infections
- Bacterial endocarditis caused by S. aureus
- Intraabdominal bacterial infections
- Pneumonia
- UTIs and pelvic infections
- Bacterial septicemia
- Gram + / gram – aerobic and anaerobic bacteria
- Interactions
- Cyclosporine
- Ganciclovir
- Probenecid
- Indications
- Contraindications
- Hypersensitivity
- Pediatric population with CNS infections
- Adverse Effects
- Seizures
- Ellderly
- Renally impaired
- Hypersensitivity
- Penicillin allergy
- Gastrointestinal
- Nausea
- Vomiting
- Diarrhea
- Dermatologic reactions
- Rash
- Phlebitis
- Seizures
Patient Education
Call your doctor if you experience any of the following:
- Seizures
- Hypersensitivity
- Penicillin allergy
- Gastrointestinal
- Nausea
- Vomiting
- Diarrhea
- Dermatologic reactions
- Rash
- Phlebitis
Transcript
Hello and welcome. Today we’re going to discuss carbapenems and the must-know information regarding these antibiotics.
Carbapenems are usually not first-line antibiotics due to their side effect profile. This class of antibiotics are bacterial beta-lactams and reserved for complicated infections like e. coli and klebsiella pneumoniae. One major side effect of carbapenems use is drug-induced seizures.
Now, carbapenems have various brand names put their generic names end in -PENEM. Carbapenems = penem ending.
The mechanism of action with carbapenems revolves around it’s inhibition of bacterial cell wall synthesis. Which leads to bacterial cell suppression and death Regardless of cellular structures, the wall synthesis impairs and destroys cellular function.
Ertapenem, is indicated in enterococcus and pseudomonas infections.
Meropenem is a well-known drug in the ICU setting and used from various complicated infections, such as pseudomonas. It’s the only carbapenem that treats bacterial meningitis.
Imipenem-cilastatin is another carbapenem used for the various well know ICU infections. If you’re patient has soft tissue infections, UTIs or bacterial septicemia, you have probably heard of this drug before.
Carbapenems potentiate the CNS effect, such as seizures when used in conjunction with medication such as cyclosporine, ganciclovir, probenecid.
Carbapenems have an extended list of adverse effects: It can cause seizures, gastrointestinal symptoms, dermatologic reactions and hypersensitivity in patients with PCN allergies. When you think of the adverse effects think of SGHD.
Nursing concepts for carbapenems include pharmacology and infection control.
Okay let’s recap – carbapenems are beta-lactam antibiotics, with ending -PENEM. These antibiotics are used to treat various infections and include profile with many side effects ( seizures, gastrointestinal symptoms, dermatologic reactions and hypersensitivity in patients with PCN allergies). One well-known important side effect is seizures and should be used with caution in children and the elderly.
You know now the important details regarding carbapenems. Now, go out and be your best self today and as always, Happy Nursing!
Medical-Surgical Nursing Study Plan
Concepts Covered:
- Cardiac Disorders
- Emergency Care of the Cardiac Patient
- Hematologic Disorders
- Acute & Chronic Renal Disorders
- Disorders of the Adrenal Gland
- Central Nervous System Disorders – Brain
- Documentation and Communication
- Preoperative Nursing
- Legal and Ethical Issues
- Immunological Disorders
- Oncology Disorders
- Female Reproductive Disorders
- Musculoskeletal Trauma
- Intraoperative Nursing
- Medication Administration
- Renal Disorders
- Disorders of Pancreas
- Shock
- Male Reproductive Disorders
- Sexually Transmitted Infections
- Infectious Respiratory Disorder
- Vascular Disorders
- Respiratory Emergencies
- Peripheral Nervous System Disorders
- Studying
- Upper GI Disorders
- Communication
- Integumentary Disorders
- Lower GI Disorders
- Urinary Disorders
- Liver & Gallbladder Disorders
- Musculoskeletal Disorders
- Circulatory System
- EENT Disorders
- Noninfectious Respiratory Disorder
- Postoperative Nursing
- Neurological Emergencies
- Neurological Trauma
- Disorders of the Posterior Pituitary Gland
- Integumentary Important Points
- Disorders of the Thyroid & Parathyroid Glands
- Microbiology
- Tissues and Glands
- Disorders of Thermoregulation
- Urinary System
- Emergency Care of the Neurological Patient
- Central Nervous System Disorders – Spinal Cord
- Renal and Urinary Disorders
- Nervous System
- Respiratory Disorders
- Respiratory System
- Neurologic and Cognitive Disorders
- Integumentary Disorders
- Infectious Disease Disorders
- Perioperative Nursing Roles
- Shock
- EENT Disorders