Anti-Infective – Antitubercular
Included In This Lesson
Outline
Overview
I. Overview
A. Mycobacterium
B. Tuberculosis (TB) infections
1. Pulmonary
2. Extrapulmonary
II. Mechanism of Action
A. Inhibit protein synthesis
B. Inhibit cell wall synthesis
III. Types (RIPES)
A. Rifampin
B. Isoniazid
C. Pyrazinamide
D. Ethambutol
E. Streptomycin
IV. Indications
A. Mycobacterium
B. Tuberculosis (TB) infections
1. Pulmonary
2. Extrapulmonary
3. TB treatment failures / relapses
V. Contraindications
A. Liver disease
B. Kidney disease
VI. Side Effects
A. CNS
1. Ototoxicity
2. Seizures
3. Visual disturbances
4. Dizziness
5. Headache
Kidney / Liver
1. Nephrotoxicity
2. Hepatoxicity
B. * Rifampin / Isoniazid
1. Red-orange-brown colored bodily secretion
2. Urine
3. Sweat
4. Tears
5. Sputum
Transcript
Welcome back and today we are going to discuss antitubercular medications.
Antitubercular medications treat mycobacterium and TB infections which are pulmonary and extrapulmonary (kidney, spine or brain). With the most common location is pulmonary.
The mechanisms of actions are the inhibition of protein synthesis (which work in RNA/DNA replication – how bacteria communicate) and cell wall synthesis (which provide structural support). There are many drugs in this drug class but each drug performs one of these actions. So this drug class stop the bacteria from being able to replicate and function. Antitubercular medications treat mycobacterium and TB infections which are pulmonary and extrapulmonary (kidney, spine or brain). With the most common location is pulmonary.
Contraindications are based in the drug’s excretion route (kidney and liver). If you have liver or kidney failure, you will not properly dispose of the drug. I had a patient with liver disease, who was administered rifampin, that drug lingered their system for days, causing all kinds of havoc. The side effect profiles are CNS and liver/kidney based. In the CNS, think ears, brain and eyes. And the drugs cause kidney and liver toxicity, which explains the contraindications mentioned earlier.
Alright, rifampin and isoniazid both have a unique side effect of red-orange-brown colored bodily secretions. I had a patient with orange sputum once, it’s something you will not forget and something you must educate your patients as a possible side effect or they will be in in the hospital freaking out! As, rightfully so.
Priority nursing concepts for a patient taking antitubercular medications include: infection control and pharmacology.
Medical-Surgical Nursing Study Plan
Concepts Covered:
- Cardiac Disorders
- Emergency Care of the Cardiac Patient
- Hematologic Disorders
- Acute & Chronic Renal Disorders
- Disorders of the Adrenal Gland
- Central Nervous System Disorders – Brain
- Documentation and Communication
- Preoperative Nursing
- Legal and Ethical Issues
- Immunological Disorders
- Oncology Disorders
- Female Reproductive Disorders
- Musculoskeletal Trauma
- Intraoperative Nursing
- Medication Administration
- Renal Disorders
- Disorders of Pancreas
- Shock
- Male Reproductive Disorders
- Sexually Transmitted Infections
- Infectious Respiratory Disorder
- Vascular Disorders
- Respiratory Emergencies
- Peripheral Nervous System Disorders
- Studying
- Upper GI Disorders
- Communication
- Integumentary Disorders
- Lower GI Disorders
- Urinary Disorders
- Liver & Gallbladder Disorders
- Musculoskeletal Disorders
- Circulatory System
- EENT Disorders
- Noninfectious Respiratory Disorder
- Postoperative Nursing
- Neurological Emergencies
- Neurological Trauma
- Disorders of the Posterior Pituitary Gland
- Integumentary Important Points
- Disorders of the Thyroid & Parathyroid Glands
- Microbiology
- Tissues and Glands
- Disorders of Thermoregulation
- Urinary System
- Emergency Care of the Neurological Patient
- Central Nervous System Disorders – Spinal Cord
- Renal and Urinary Disorders
- Nervous System
- Respiratory Disorders
- Respiratory System
- Neurologic and Cognitive Disorders
- Integumentary Disorders
- Infectious Disease Disorders
- Perioperative Nursing Roles
- Shock
- EENT Disorders