Skeletal Muscle

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Myocyte (Image)
Skeletal Myocytes (Image)
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Outline

Overview

  1. Gross structure of skeletal muscle
    1. Epimysium
      1. WFCT around every muscle
      2. Blends with tendon
      3. Holds fascicles together
    2. Perimysium
      1. WFCT surrounds groups of cells called fascicles
    3. Endomysium
      1. Collagen fibers which surround individual muscle cells
    4. Pathway for BV’s and nerves to get to cells
      1. Epimysium → perimysium → endomysium → cell

Nursing Points

General

  1. Ultrastructure of skeletal muscle
    1. Sarcolemma = cell membrane
    2. Sarcoplasm = cytoplasm
      1. Mitochondria—ATP formation
      2. Myofibrils
        1. Contractile units
        2. Made of myofilaments
          1. Thick filaments (myosin)
          2. Thin filaments (actin, tropomyosin, troponin)
        3. Banding patterns
          1. Dark band = A band
          2. Light band = I band
          3. Create cross striations
        4. Microscopic structure of myofibrils
          1. A band includes thick filaments
          2. I band includes thin filaments
          3. Bands separated by Z line
          4. H zone (M line in center)
            1. Light region in the middle of the A band
            2. No thin filaments
          5. A band is dark because it contains thick AND thin filaments
          6. I band is light because it had NO thick filaments
          7. Sarcomere
            1. Smallest unit of muscle contraction (ultrastructural)
            2. Between 2 adjacent Z lines
    3. T-system (transverse)
      1. System of open tubules
        1. Begin as pores in sarcolemma
        2. Long tubule into sarcoplasm
          1. Between myofibrils
        3. Function
          1. Transfer an action potential from sarcolemma to myofilaments
    4. Sarcoplasmic reticulum
      1. Close system of tubules in sarcoplasm
        1. Reticular network (central)
        2. Sarcotubules extend laterally from network
        3. Terminal cysternae (lateral sacs) at the ends
        4. Function:
          1. Regulation of Calcium within sarcoplasm
    5. “Triads”
      1. Central T-tubule
      2. 2 lateral cysternae

References
Betts, J.G., et al. (2017). Anatomy and physiology. Houston, TX: OpenStax, Rice University. Retrieved from https://openstax.org/details/books/anatomy-and-physiology?Book%20details

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Transcript

In this lesson, we’re going to take a look at the gross structure and function of skeletal muscle.

To get started let’s look at the overall structure of skeletal muscle. At the base level, you have an individual muscle cell that is surrounded by collagen fibers. This is called the endomysium. As individual muscle cells become bundled together they are surrounded by white fibrous connective tissue and they are call fascicles. These fascicles are covered by this white fibrous connective tissue and we call this the perimysium. As all of those bundles of fascicles come together they form the actual whole skeletal muscle. This muscle is surrounded by the White fibrous connective tissue, and that blends with the tendon that attaches to the bone. This white fibrous connective tissue holds the fascicles altogether, and it’s called the epimysium. Now I’m sure you’re wondering how blood and nerves get to all of those individual muscle cells. Well starts from the outside and moves in. You have the epimysium, they move into the perimysium, they move further into the end of my team, and then they go to the cell and provide the nutrients and remove waste.

So let’s start with the basic unit of a muscle cell. You have the sarcolemma which is the cell membrane, and you have the sarcoplasm which is essentially the muscle cell cytoplasm. Then you have this thing called the myofibril which is the contractile unit of skeletal muscle. You have the six elements which are known as myosin, and then you have the thin filaments which are known as actin tropomyosin and troponin. You also start to get these banding patterns, which are the light and dark bands. The dark band is known as the a band, and the light band is known as the iban. When you have this alternating powder of dark and light bands you get the striated colors of skeletal muscle.

Okay so what’s in a myofibril? Let’s start with the band. Give it a band and then I van. And a van has thick filaments, so that’s myosin. The iban has the thin filaments, so that Acton, troponin, and tropomyosin. Now what happens is during muscle contraction the sarcomere, which is the functional unit shortens and you have this overlapping of these band. This overlap occurs in the H Zone, along that the M line. The whole sarcomere itself is separated by the Z discs or Z lines, and it is the functional unit and the smallest unit of muscle contraction.

Now that we’ve gotten that out of the way, let’s look at the T system. The T system is the transverse system, and what happens is the sarcolemma which is the cell membrane, needs to get information inside of it. And the way that says this is to these long tubules in the sarcoplasm. What happens is as the nurse comes in and sends an action potential from the nervous system to the muscle cells it’s transferred through this tube system. The signal is sent from the outside of the cell membrane all the way down to the myofilaments and causes the muscle contraction.

So now that you understand how it gets in the outside of the cell down into the myofilaments, we need to look at the structure of something called the sarcoplasmic reticulum and Triads. Now the sarcoplasmic reticulum is the closest mm of tubules inside the sarcoplasm. So this is the tubules in the cytoplasm of the muscle cell. There is a central network of reticulum call the reticular Network here and this goes out to the circle tubules which extend laterally so away from the middle. At the end you has something called terminal cisternae. The whole purpose of the sarcoplasmic reticulum is to regulate calcium within the sarcoplasm, and it does this with calcium channels. In each section you’ll have something called a Triad. The Triad consists of a central t-tubule and two lateral cisternae on each side.

Okay so let’s recap. All of the layers of muscle have connective tissue. You have the endomysium, perimysium, and epimysium. The myofibrils are the Contractile units of the muscle cell, and they consist of the sarcolemma, sarcoplasm Anna and the contractile filaments myosin, Acton, tropomyosin, and troponin. Myofibrils structure. This is your iban, you’re a band, your H Zone with your in line, and the Z disc which go from each end of the sarcomere. The T system is the tubules system which allows Action potentials to go from the neuron all the way to the inside of the cell. The sarcoplasmic reticulum is a system of tubules that regulate calcium in the sarcoplasm with calcium channel.

That’s it for a lesson on skeletal muscle and all the components to go into it. Make sure you check out all the resources attached to this lesson. Now, go out and be your best selves today, and as always happy nursing

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A & P

Concepts Covered:

  • Cardiovascular
  • Circulatory System
  • Nervous System
  • Skeletal System
  • Emergency Care of the Cardiac Patient
  • Neurological
  • Respiratory
  • Urinary System
  • Respiratory System
  • Endocrine System
  • Studying
  • Tissues and Glands
  • Medication Administration
  • Hematologic System
  • Digestive System
  • Reproductive System
  • Endocrine and Metabolic Disorders
  • Preoperative Nursing
  • Integumentary Disorders
  • Urinary Disorders
  • Muscular System
  • Noninfectious Respiratory Disorder
  • Sensory System
  • Basics of Human Biology

Study Plan Lessons

02.03 Swan-Ganz Catheters for CCRN Review
02.04 Pulmonary Artery Wedge Pressure (PAWP) for CCRN Review
02.05 Calculating PAWP on PEEP for CCRN Review
02.07 Reading “A, C, V Waves” & PAWP Waveforms for CCRN Review
02.09 12 Lead EKG- Leads 1, 2, 3, aVL, and aVF for CCRN Review
02.10 12 Lead EKG- Lead V1-V6 for CCRN Review
02.11 12 Lead EKG- Injuries for CCRN Review
07.02 Neuro Anatomy for CCRN Review
10.01 Arterial Blood Gas (ABG) Interpretation for CCRN Review
10.02 Breath Sounds for CCRN Review
ABG Course (Arterial Blood Gas) Introduction
Adrenal Gland
Alkalosis and Acidosis Nursing Mnemonic (Kick Up, Drop Down)
Anatomy & Physiology Course Introduction
Anticholinergics – Side Effects Nursing Mnemonic (4 Can’ts)
Arterial Blood Gases Nursing Mnemonic (ROME)
Arterial Pressure Monitoring
Atropine (Atropen) Nursing Considerations
Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
Beta 1 and Beta 2 Nursing Mnemonic (1 Heart, 2 Lungs)
Blood Grouping
Blood Plasma
Blood Pressure (BP) Control
Blood Vessels
Bone Structure
Bowel Elimination
Breathing Control
Breathing Movements
Calcium and Magnesium Imbalance for Certified Emergency Nursing (CEN)
Calculating Heart Rate
Cardiac (Heart) Physiology
Cardiac A&P Module Intro
Cardiac Cycle
Causes of Poor Gas Exchange Nursing Mnemonic (All People Can Value Lungs)
Cholinergic Crisis – Signs and Symptoms Nursing Mnemonic (SLUDGE)
Connective Tissues
Cranial Nerves
Development of Bones
Digestion & Absorption
Digestive System Anatomy
Drawing Blood
Drawing Blood from the IV
EKG (ECG) Course Introduction
EKG (ECG) Waveforms
EKG Basics – Live Tutoring Archive
Electrical A&P of the Heart
Electrical Activity in the Heart
Electroencephalography (EEG)
Electrolyte Imbalances for Progressive Care Certified Nurse (PCCN)
Electrolytes – Location in Body Nursing Mnemonic (PISO)
Electrolytes Involved in Cardiac (Heart) Conduction
Electromyography (EMG)
Epithelial (Skin) Tissues
Esophagus
Female Reproductive Anatomy (Anatomy and Physiology)
Fluid & Electrolytes Course Introduction
Fluid Volume Deficit
Formation & Excretion of Urine
Gastrointestinal (GI) Course Introduction
Glands
Health Assessment Course Introduction
Hygiene
Hyperkalemia – Causes Nursing Mnemonic (MACHINE)
Hyperkalemia – Management Nursing Mnemonic (AIRED)
Hyperkalemia – Signs and Symptoms Nursing Mnemonic (Murder)
Hypernatremia – Causes Nursing Mnemonic (MODEL)
Increase MAP Nursing Mnemonic (VAK)
Inserting a Foley (Urinary Catheter) – Male
Intro to Circulatory System
Intro to Health Assessment
Introduction to Health Assessment
Joints
Large Intestine
Liver & Gallbladder
Male Reproductive Anatomy (Anatomy and Physiology)
Membrane Potentials
Membranes
Mouth & Oropharynx
Muscle Anatomy (anatomy and physiology)
Muscle Contraction
Muscle Cytology
Muscle Physiology
Nerve Transmission
Nervous System Anatomy
Neuro Assessment Module Intro
Normal Sinus Rhythm
Nursing Care Plan (NCP) for Bronchoscopy (Procedure)
Nursing Care Plan (NCP) for Fluid Volume Deficit
Order of Lab Draws
Oxygen Delivery Module Intro
Pancreas
Parasympathomimetics (Cholinergics) Nursing Considerations
Pituitary Gland
Renal (Kidney) Acid-Base Balance
Renal (Kidney) Fluid & Electrolyte Balance
Renal (Kidney) Structure & Function
Renin Angiotensin Aldosterone System
Renin Angiotensin Aldosterone System (RAAS)
Respiratory A&P Module Intro
Respiratory Functions of Blood
Respiratory Structure & Function
Selecting THE vein
Sensory Basics
Skeletal Anatomy
Skeletal Muscle
Skin Structure & Function
Small Intestine
Sodium and Potassium Imbalance for Certified Emergency Nursing (CEN)
Spinal Cord
Stomach Video
Tattoos IV Insertion
The EKG (ECG) Graph
The Heart
Thyroid Gland
Tonicity of Solutions – Live Tutoring Archive
Trach Care
Trach Suctioning
Two pathways of the peripheral nervous system Nursing Mnemonic (SAME)
Types of Epithelial (Skin) Tissue
Urinary Elimination
Urinary System Anatomy (Anatomy and Physiology)