Malignant Hyperthermia

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Outline

Overview

  1. Malignant hyperthermia (MH)
    1. Rare
    2. Life threatening complication
    3. Associated with anesthesia drugs
      1. Most common
        1. Inhalation anesthetics
        2. Succinylcholine
    4. Occurs in who?
      1. Most often
        1. Children
        2. Adolescents
      2. Genetic concerns
        1. Increase incidence in
          1. Muscular dystrophies
          2. Central core diseases
    5. Hypermetabolic condition
      1. Increased body temperature
      2. See additional signs and symptoms
    6. When can signs occur?
      1. With anesthesia
        1. Induction
        2. Maintenance
        3. Postoperatively
        4. Repeated exposures
    7. Managed by
      1. Anesthesia team
      2. Perioperative team

Nursing Points

General

  1. Signs and symptoms
    1. Hypercarbia
    2. Muscle stiffness
    3. Tachypnea
      1. May not see in paralyzed patient
    4. Dark blood
      1. Seen at operative field
    5. Tachycardia
    6. Hypoxia
    7. Metabolic and respiratory acidosis
    8. Cardiac arrhythmias
    9. Elevation of body temperature
      1. 1 to 2 Celsius degrees every 5 minutes
      2. One of the LAST things to occur!

Assessment

  1. Assess patient before
    1. History of anesthesia reactions
      1. “High fever”
      2. Family history
        1. Has anyone died during surgery?
    2. Genetic issues
    3. Age
  2. If MH suspected
    1. Patient can still have surgery
    2. Anesthesia drugs adjusted
      1. Per anesthesia team

Therapeutic Management

  1. Know facility/anesthesia protocol
    1. Emergency MH cart
      1. Location
      2. What it includes
        1. Medications
        2. Lab tubes
        3. IV solutions
        4. Location of chilled solutions
    2. Time is crucial!
    3. Know your role
  2. Treatment of MH
    1. Primary drug
      1. Dantrolene
        1. Muscle relaxant
    2. Cold IV solutions
    3. Diuretics
    4. Treating cardiac arrhythmias
    5. Correcting acid-base issues
    6. Monitor
      1. Fluid intake
      2. Output

Nursing Concepts

  1. Clinical judgement
  2. Safety
  3. Teamwork & Collaboration

Patient Education

  1. Teach patient
    1. Provide a full medical history
      1. Issues with anesthesia
        1. Personal or family history
    2. Ask questions!

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Transcript

Hi guys!  Today I am going to talk to you a little bit about malignant hyperthermia and the surgery patient.

So what is malignant hyperthermia?  Guys I will be honest this is something we as the perioperative team especially anesthesia take super seriously!  This condition is rare but extremely life threatening to a patient if it occurs! It can be triggered by certain medications that are given to put the patient under general anesthesia for their surgery.  It can occur in anyone but is commonly seen in children, adolescents, and has an increased incidence with certain genetic conditions like some muscular dystrophies. Guys prevention is key with MH!

So it’s super important to know the signs and symptoms so we can act quickly!  Hypercarbia, muscle stiffness or rigidity are seen. Also tachypnea can be seen but possibly not if the patient has been paralyzed for the surgery.  Also the patients blood may look very desaturated or dark at the surgical field. A high heart rate, low oxygen saturation and acidosis, metabolic and respiratory can be seen too.

Now here is the sign that gives this condition its name!  One of the last signs that is seen is an elevated body temperature and guys it will rise 1 to 5 celsius degrees every 5 minutes!  This is why it is important to recognize initial signs and symptoms to stop this from happening immediately!

So when can malignant hyperthermia occur?  So the signs can occur during induction or maintenance of anesthesia and also after the procedure.  And guys it might not occur after the first time with anesthesia but it could occur after the second surgery!  Guys I have been a surgery nurse for a long time and I will be honest I haven’t seen malignant hyperthermia! I will attribute this to a great assessment by anesthesia and the perioperative team and also a protocol in place that everyone is aware of!  And I just want to mention that we need to be prepared for malignant hyperthermia in settings other than the operating room especially in the ER where patients may be given anesthetic medications like emergent intubation! We always have to be ready for malignant hyperthermia when anesthesia is involved!

Ok so in terms of malignant hyperthermia what should we assess in the patient?  We want to ask our patients if they have ever had any issues that they can remember with anesthesia in the past.  Patients are not always good historians so asking them about “high fevers” or “heat strokes” during or after surgery can help them to remember.  Also sometimes patients might say that they’ve never had surgery but they did have a family member who died during surgery, this could be an indication of MH.  Also assess the patient for any genetic conditions that could increase their risk as well as their age.

Ok guys what do we do if we suspect that our patient may have had or has a family history of malignant hyperthermia?  It is super important to know your facility protocol and guidelines for this issue. So know your role in this situation!  Most facilities, the hospital where I work included, typically have an emergency malignant hyperthermia cart. If we think there is a chance of malignant hyperthermia the cart will be placed outside of the OR so it is readily available.  You should also be aware of what is inside the cart so you have everything you need. Time is critical and crucial to your patient’s life if they have malignant hyperthermia!

So what do we use to treat the patient who is showing signs of malignant hyperthermia? The primary drug used to treat this issue is dantrolene which is a muscle relaxant. The patient will also be treated with cold IV solutions, diuretics, arrhythmias and acid-base issues will be corrected, and fluid intake and output will be monitored.  Instructions and supplies are typically included with the emergency MH cart.

Okay so which nursing concepts can we apply to malignant hyperthermia? Clinical judgement is crucial for the safety of the malignant hyperthermia patient. The anesthesia team and perioperative team members will work together and collaborate for prevention of malignant hyperthermia or treatment if necessary.

Okay so let’s look at a few key points of malignant hyperthermia. This condition is rare but life-threatening if it occurs.   It’s commonly associated with general anesthesia medications, it can occur in anyone but there is an increased incidence in children, adolescents, and patients with certain genetic conditions.  Signs of malignant hyperthermia are hypercarbia, hypoxia, muscle stiffness or rigidity, dark blood that can be seen during surgery and one of the last signs to occur is an elevated temperature. We will assess our patients preoperatively for any history of anesthesia reactions or a “high fever” that they can remember during or after a surgery. We are also going to ask them about any family history of anesthesia reactions. If we recognize something we will notify anesthesia and they can alter their anesthesia medications for prevention.   Know your facilities policy and guidelines and also where your emergency MH cart is. If MH occurs in your patient dantrolene is the primary drug for treatment. We also use chilled IV solutions, treat acid base issues and cardiac arrhythmias, and diuretics are also given. We teach our patients to provide a thorough medical and surgical history and also a family history and as always they can ask questions!

Okay guys I hope you enjoyed this lesson and learned important information on malignant hyperthermia!  Make sure you check out all the resources attached to this lesson, as well as the rest of the lessons in this course. Now, go out and be your best self today. And, as always, happy nursing!

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Concepts Covered:

  • Gastrointestinal
  • Upper GI Disorders
  • Respiratory Emergencies
  • Immunological Disorders
  • Hematologic Disorders
  • Intraoperative Nursing
  • Medication Administration
  • Newborn Complications
  • Noninfectious Respiratory Disorder
  • Peripheral Nervous System Disorders
  • Studying
  • Central Nervous System Disorders – Brain
  • Sexually Transmitted Infections
  • Infectious Respiratory Disorder
  • Disorders of Pancreas
  • Liver & Gallbladder Disorders
  • Disorders of Thermoregulation
  • Musculoskeletal Trauma
  • Disorders of the Posterior Pituitary Gland
  • Cardiac Disorders
  • Emergency Care of the Cardiac Patient
  • Emergency Care of the Trauma Patient
  • Neurological Trauma
  • Disorders of the Thyroid & Parathyroid Glands
  • Male Reproductive Disorders
  • Oncology Disorders
  • Postoperative Nursing
  • Renal Disorders
  • Renal and Urinary Disorders
  • Central Nervous System Disorders – Spinal Cord
  • Integumentary Disorders
  • Shock
  • Acute & Chronic Renal Disorders
  • Respiratory Disorders
  • Vascular Disorders
  • Lower GI Disorders
  • Respiratory System
  • Disorders of the Adrenal Gland
  • Neurologic and Cognitive Disorders
  • Infectious Disease Disorders
  • Female Reproductive Disorders
  • EENT Disorders
  • Respiratory
  • Emergency Care of the Respiratory Patient
  • Neurological Emergencies
  • Communication

Study Plan Lessons

05.01 Pancreatitis and Large Bowel Obstruction for CCRN Review
Acute Respiratory Distress Syndrome (ARDS) for Progressive Care Certified Nurse (PCCN)
AIDS Case Study (45 min)
Airway Suctioning
Anemia for Progressive Care Certified Nurse (PCCN)
Anesthetic Agents
Anesthetic Agents
ARDS Case Study (60 min)
ARDS causes Nursing Mnemonic (GUT PASS)
Artificial Airways
Aspiration for Certified Emergency Nursing (CEN)
Assessment for Myasthenic Crisis Nursing Mnemonic (BRISH)
Asthma for Certified Emergency Nursing (CEN)
AVPU Mnemonic (The AVPU Scale)
Azithromycin (Zithromax) Nursing Considerations
Barbiturates
Brain Death v. Comatose
Brain Tumors
Bronchoscopy
Carbon Dioxide (Co2) Lab Values
Chest Tube Management
Chest Tube Management Case Study (60 min)
Chronic Obstructive Pulmonary Disease (COPD) Case Study (60 min)
Chronic Obstructive Pulmonary Disease (COPD) for Certified Emergency Nursing (CEN)
Cirrhosis Case Study (45 min)
Cold Temperature-related Emergencies for Certified Emergency Nursing (CEN)
Complications of Immobility
Coronavirus (COVID-19) Nursing Care and General Information
Day in the Life of a Med-surg Nurse
Diabetes Insipidus Case Study (60 min)
Diabetes Mellitus Case Study (45 min)
Diabetic Ketoacidosis (DKA) Case Study (45 min)
Disseminated Intravascular Coagulation Case Study (60 min)
Dysrhythmias for Certified Emergency Nursing (CEN)
Enteral & Parenteral Nutrition (Diet, TPN)
Erythromycin (Erythrocin) Nursing Considerations
Fractures (Open, Closed, Fat Embolus) for Certified Emergency Nursing (CEN)
General Anesthesia
Head and Spinal Cord Trauma for Certified Emergency Nursing (CEN)
Heart Failure Case Study (45 min)
Heart Failure for Certified Emergency Nursing (CEN)
Hemorrhagic Fevers for Certified Emergency Nursing (CEN)
Histamine 1 Receptor Blockers
Hyperthyroidism Case Study (75 min)
Hypothermia (Thermoregulation)
Infectious Diseases: Influenza for Progressive Care Certified Nurse (PCCN)
Intraoperative (Intraop) Complications
Leukemia Case Study (60 min)
Levofloxacin (Levaquin) Nursing Considerations
Local Anesthesia
Lung Cancer
Malignant Hyperthermia
Melanoma
Meperidine (Demerol) Nursing Considerations
Metabolic Acidosis (interpretation and nursing diagnosis)
Miscellaneous Nerve Disorders
Moderate Sedation
Montelukast (Singulair) Nursing Considerations
Morphine (MS Contin) Nursing Considerations
Myocardial Infarction (MI) Case Study (45 min)
Nephrotic Syndrome Case Study (Peds) (45 min)
Neurological Disorders (Multiple Sclerosis, Myasthenia Gravis, Guillain-Barré Syndrome) for Certified Emergency Nursing (CEN)
Noncardiac Pulmonary Edema for Certified Emergency Nursing (CEN)
Nursing Care and Pathophysiology for Acquired Immune Deficiency Syndrome (AIDS)
Nursing Care and Pathophysiology for Anaphylaxis
Nursing Care and Pathophysiology for Asthma
Nursing Care and Pathophysiology for Influenza (Flu)
Nursing Care and Pathophysiology for Myasthenia Gravis
Nursing Care and Pathophysiology for Psoriasis
Nursing Care and Pathophysiology for Scleroderma
Nursing Care and Pathophysiology for Sepsis
Nursing Care and Pathophysiology for SIRS & MODS
Nursing Care and Pathophysiology of Acute Respiratory Distress Syndrome (ARDS)
Nursing Care and Pathophysiology of Chronic Kidney (Renal) Disease (CKD)
Nursing Care and Pathophysiology of Diabetic Ketoacidosis (DKA)
Nursing Care and Pathophysiology of Glomerulonephritis
Nursing Care and Pathophysiology of Pneumonia
Nursing Care Plan (NCP) & Interventions for Increased Intracranial Pressure (ICP)
Nursing Care Plan (NCP) for Activity Intolerance
Nursing Care Plan (NCP) for Acute Bronchitis
Nursing Care Plan (NCP) for Acute Kidney Injury
Nursing Care Plan (NCP) for Acute Respiratory Distress Syndrome
Nursing Care Plan (NCP) for Anaphylaxis
Nursing Care Plan (NCP) for Anemia
Nursing Care Plan (NCP) for Angina
Nursing Care Plan (NCP) for Aortic Aneurysm
Nursing Care Plan (NCP) for Aspiration
Nursing Care Plan (NCP) for Asthma / Childhood Asthma
Nursing Care Plan (NCP) for Blunt Chest Trauma
Nursing Care Plan (NCP) for Bowel Obstruction
Nursing Care Plan (NCP) for Brain Tumors
Nursing Care Plan (NCP) for Bronchoscopy (Procedure)
Nursing Care Plan (NCP) for Cardiogenic Shock
Nursing Care Plan (NCP) for Chronic Kidney Disease
Nursing Care Plan (NCP) for Chronic Obstructive Pulmonary Disease (COPD)
Nursing Care Plan (NCP) for Congestive Heart Failure (CHF)
Nursing Care Plan (NCP) for Cushing’s Disease
Nursing Care Plan (NCP) for Diabetes Insipidus
Nursing Care Plan (NCP) for Diabetic Ketoacidosis (DKA)
Nursing Care Plan (NCP) for Disseminated Intravascular Coagulation (DIC)
Nursing Care Plan (NCP) for Diverticulosis / Diverticulitis
Nursing Care Plan (NCP) for Emphysema
Nursing Care Plan (NCP) for Encephalopathy
Nursing Care Plan (NCP) for Endocarditis
Nursing Care Plan (NCP) for Gastroesophageal Reflux Disease (GERD)
Nursing Care Plan (NCP) for GI (Gastrointestinal) Bleed
Nursing Care Plan (NCP) for Guillain-Barre
Nursing Care Plan (NCP) for Heart Valve Disorders
Nursing Care Plan (NCP) for Hydrocephalus
Nursing Care Plan (NCP) for Hyperosmolar Hyperglycemic Nonketotic Syndrome (HHNS)
Nursing Care Plan (NCP) for Hyperthermia (Thermoregulation)
Nursing Care Plan (NCP) for Hyperthyroidism
Nursing Care Plan (NCP) for Hypovolemic Shock
Nursing Care Plan (NCP) for Lung Cancer
Nursing Care Plan (NCP) for Lymphoma (Hodgkin’s, Non-Hodgkin’s)
Nursing Care Plan (NCP) for Mumps
Nursing Care Plan (NCP) for Myasthenia Gravis (MG)
Nursing Care Plan (NCP) for Myocardial Infarction (MI)
Nursing Care Plan (NCP) for Nephrotic Syndrome
Nursing Care Plan (NCP) for Osteoporosis
Nursing Care Plan (NCP) for Pancreatitis
Nursing Care Plan (NCP) for Pericarditis
Nursing Care Plan (NCP) for Restrictive Lung Diseases
Nursing Care Plan (NCP) for Rubeola – Measles
Nursing Care Plan (NCP) for Spinal Cord Injury
Nursing Care Plan (NCP) for Syncope (Fainting)
Nursing Care Plan (NCP) for Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
Nursing Care Plan (NCP) for Thoracentesis (Procedure)
Nursing Care Plan (NCP) for Thrombophlebitis / Deep Vein Thrombosis (DVT)
Nursing Care Plan (NCP) for Tuberculosis
Nursing Care Plan for Cirrhosis (Liver)
Nursing Care Plan for Distributive Shock
Nursing Care Plan for Nasal Disorders
Nursing Care Plan for Pulmonary Edema
Nursing Care Plan for Restrictive Lung Diseases (Pulmonary Fibrosis, Neuromuscular Disorders)
Nursing Care Plan for Scleroderma
Nursing Case Study for Breast Cancer
Nursing Case Study for Cardiogenic Shock
Nursing Case Study for Hepatitis
Nursing Case Study for Pneumonia
Nursing Case Study for Type 1 Diabetes
Obstruction for Certified Emergency Nursing (CEN)
Obstructive Sleep Apnea for Progressive Care Certified Nurse (PCCN)
Ondansetron (Zofran) Nursing Considerations
Opioids
Pancreatitis For PCCN for Progressive Care Certified Nurse (PCCN)
Patient Positioning
Pentobarbital (Nembutal) Nursing Considerations
Peritonitis for Certified Emergency Nursing (CEN)
Pleural Space Complications (Pneumothorax, Hemothorax, Pleural Effusion, Empyema, Chylothorax) for Progressive Care Certified Nurse (PCCN)
Positioning (Pressure Injury Prevention and Tourniquet Safety) for Certified Perioperative Nurse (CNOR)
Post-Anesthesia Recovery
PPE Precautions (Personal Protective Equipment) for Certified Perioperative Nurse (CNOR)
Propofol (Diprivan) Nursing Considerations
Respiratory A&P Module Intro
Respiratory Alkalosis
Respiratory Course Introduction
Respiratory Depression (Medication-Induced, Decreased-LOC-Induced) for Progressive Care Certified Nurse (PCCN)
Respiratory Distress Syndrome for Certified Emergency Nursing (CEN)
Respiratory Failure (Acute, Chronic, Failure to Wean) for Progressive Care Certified Nurse (PCCN)
Respiratory Infections (Pneumonia) for Progressive Care Certified Nurse (PCCN)
Respiratory Infections Module Intro
Respiratory Procedures Module Intro
Respiratory Trauma for Certified Emergency Nursing (CEN)
Respiratory Trauma Module Intro
Rheumatoid Arthritis Assessment Nursing Mnemonic (RHEUMATOID)
Shock States (Anaphylactic, Hypovolemic) For PCCN for Progressive Care Certified Nurse (PCCN)
Spinal Cord Injury Case Study (60 min)
Stroke Assessment (CVA)
Surgical Wound Classification Documentation for Certified Perioperative Nurse (CNOR)
Systemic Lupus Erythematosus (SLE)
The Medical Team
Thoracentesis
Trach Suctioning
Tuberculosis for Certified Emergency Nursing (CEN)
Vaccine-Preventable Diseases (Measles, Mumps, Pertussis, Chicken Pox, Diphtheria) for Certified Emergency Nursing (CEN)
Ventilator Settings
Wound Dressing Maintenance for Certified Perioperative Nurse (CNOR)