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Alteplase (tPA, Activase) Nursing Considerations

Alteplase (tPA, Activase) Nursing Considerations

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Outline

Generic Name

Alteplase

Trade Name

tPA, Activase

Indication

MI, acute ischemic stroke, occluded central lines

Action

Converts plasminogen to plasmin which degrades the fibrin found in clots

Therapeutic Class

Thrombolytics

Pharmacologic Class

Plasminogen activators

Nursing Considerations

• Contraindicated in active bleeding
• Monitor closely for signs of bleeding (petechiae)
○ q 15 min X1hr o q 15-30 min X 8 hr
• Use caution with patient who have had recent surgery
• May cause intracranial hemorrhage
• Monitor for anaphylaxis
• Use caution with uncontrolled hypertension
• Assess neuro status during therapy

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Pharm 1

Concepts Covered:

Test Taking Strategies
Learning Pharmacology
Medication Administration
Dosage Calculations
Adult
Emergency Care of the Cardiac Patient
Cardiac Disorders
Cardiovascular Disorders
Vascular Disorders
Hematologic Disorders
Acute & Chronic Renal Disorders
Disorders of Pancreas
Female Reproductive Disorders
Immunological Disorders
Urinary System
Central Nervous System Disorders – Brain
Pregnancy Risks
Neurological
Disorders of the Posterior Pituitary Gland
Shock
Male Reproductive Disorders
Urinary Disorders

Study Plan Lessons

12 Points to Answering Pharmacology Questions

The SOCK Method – Overview

The SOCK Method – S

The SOCK Method – O

The SOCK Method – C

The SOCK Method – K

Basics of Calculations

Dimensional Analysis Nursing (Dosage Calculations/Med Math)

IV Infusions (Solutions)

Complex Calculations (Dosage Calculations/Med Math)

Interactive Practice Drip Calculations

Pediatric Dosage Calculations

ACLS (Advanced cardiac life support) Drugs

Amiodarone (Pacerone) Nursing Considerations

Adenosine (Adenocard) Nursing Considerations

Procainamide (Pronestyl) Nursing Considerations

Anti-Platelet Aggregate

Clopidogrel (Plavix) Nursing Considerations

Warfarin (Coumadin) Nursing Considerations

Thrombin Inhibitors

Enoxaparin (Lovenox) Nursing Considerations

Heparin (Hep-Lock) Nursing Considerations

Alteplase (tPA, Activase) Nursing Considerations

Streptokinase (Streptase) Nursing Considerations

Antidiabetic Agents

Glipizide (Glucotrol) Nursing Considerations

Metformin (Glucophage) Nursing Considerations

Insulin – Rapid Acting (Novolog, Humalog) Nursing Considerations

Insulin – Short Acting (Regular) Nursing Considerations

Insulin – Intermediate Acting (NPH) Nursing Considerations

Insulin – Mixtures (70/30)

Insulin – Long Acting (Lantus) Nursing Considerations

Essential NCLEX Meds by Class

Renin Angiotensin Aldosterone System

Sympatholytics (Alpha & Beta Blockers)

Atenolol (Tenormin) Nursing Considerations

Metoprolol (Toprol XL) Nursing Considerations

Propranolol (Inderal) Nursing Considerations

ACE (angiotensin-converting enzyme) Inhibitors

Captopril (Capoten) Nursing Considerations

Enalapril (Vasotec) Nursing Considerations

Lisinopril (Prinivil) Nursing Considerations

Angiotensin Receptor Blockers

Losartan (Cozaar) Nursing Considerations

Calcium Channel Blockers

Amlodipine (Norvasc) Nursing Considerations

Diltiazem (Cardizem) Nursing Considerations

Nifedipine (Procardia) Nursing Considerations

Verapamil (Calan) Nursing Considerations

Cardiac Glycosides

Digoxin (Lanoxin) Nursing Considerations

Diuretics (Loop, Potassium Sparing, Thiazide, Furosemide/Lasix)

Furosemide (Lasix) Nursing Considerations

Hydrochlorothiazide (Hydrodiuril) Nursing Considerations

Spironolactone (Aldactone) Nursing Considerations

Mannitol (Osmitrol) Nursing Considerations

Glucagon (GlucaGen) Nursing Considerations

HMG-CoA Reductase Inhibitors (Statins)

Atorvastatin (Lipitor) Nursing Considerations

Magnesium Sulfate

Nitro Compounds

Nitroglycerin (Nitrostat) Nursing Considerations

Nitroprusside (Nitropress) Nursing Considerations

Epinephrine (EpiPen) Nursing Considerations

Norepinephrine (Levophed) Nursing Considerations

Vasopressin (Pitressin) Nursing Considerations

Anti-Infective – Sulfonamides

Trimethoprim-Sulfamethoxazole (Bactrim) Nursing Considerations