Epoetin Alfa
Overview Colony-stimulating factors Two types Epoetin Alfa Increases red blood cells Mechanism of action Epoetin Alfa acts like erythropoietin (a factor usually produced by the kidneys when RBC’s are low) Stimulates the bone marrow to produce RBC’s Indications Anemia caused by Chronic Kidney Failure Patient with HIV Patients recieving chemotherapy Filigrastim and Sargramostim Increases white […]
Hydralazine
Overview Hydralazine- direct acting vasodilator Indications Hypertension Heart failure Mechanism of action Unclear 3 types of mechanism suggested Releases nitric oxide from vascular endothelial cells causing vasodilation Blocks the entry of calcium in the smooth muscle cells and causing vasodilation. Opening the potassium channels causing the hyperpolarization and causing the vasodilation General Hydralazine is often […]
Pharmacokinetics
“Add Me” – These are the 4 steps/components of pharmacokinetics, or how the body processes a drug. Absorption is getting the drug into the systemic circulation, Distribution is getting the drug to the target organs, Metabolism (performed by the Cytochrome P450 system) is making the drug active and excretable, and Excretion is the process of […]